Diners' Choice: American restaurants in Mississippi

OpenTable

Updated 05 November 2026

Looking for restaurants with the best overall American cuisine in Mississippi? You’re in the right place. Each month OpenTable analyses more than 400,000 new diner reviews. We sort the results by category to help you discover new favourites. It's a great partnership: you reserve, eat, and review. We listen...and deliver the results for all to benefit. Enjoy!

Maison De Lu

4.9

4.9 (629)

$30 and under

American

Ocean Springs

About the restaurant

LUNCH M-Sat 11am-2pm (First come first serve)
We only take lunch reservations for groups 6 or more. (228) 875-0032

DINNER Tues-Sat 4pm-9pm (Reservations Highly Suggested)

* Voted BEST DATE NIGHT SPOT
* Voted BEST REHEARSAL DINNER VENUE in Mississippi
*We are lively and energetic! Opt for outdoors for a quieter experience!
*OUTDOOR TABLES are HEATED
*Please carefully select Courtyard or Front Porch when choosing outdoor dining.
*Reservations required for dinner only.
* Parties of 12 guests or larger are only done via phone.

***REQUESTS FOR CERTAIN TABLES AND/OR MOVING INDOORS OR OUTDOORS ARE NOT PROMISED BUT WE WILL DO OUR BEST

Top review

Lisa

Dined 1 day ago

The veal chop and lamb chops were exceptional. Had a pomegranate martini which was delicious. Arthur was our server and again he was great.

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Popular dish

Crab Claws

Popular dish

White Chocolate Bread Pudding

Phillip M's

4.8

4.8 (557)

$31 to $50

American

Philadelphia

About the restaurant

Phillip M’s is considered the best fine dining restaurant in the South, receiving Wine Spectator’s “Award of Excellence" in 2022 & 2023. Phillip M’s, named in honor of the late Tribal Chief Phillip Martin, received 2014’s Best of Southern Gaming Awards for Best Restaurant.

In addition to its award-winning wines, Phillip M’s offers a brand-new menu featuring everything from fine steaks, fresh seafood, and extraordinary wines to decadent desserts. Signature dishes include 16oz. Bone in Ribeye, Shrimp, and Salmon.

Top review

Lisa

Dined on 17 Oct 2026

Our experience was awesome. We had a private dining room with our personal server. She was phenomenal & the food was wonderful.

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4.8

4.8 (1267)

$30 and under

American

Oxford

About the restaurant

McEwen's Oxford is passionate about food, wine, and you! We strive to create a place you long to come back to again and again. With an eclectic blend of styles, McEwen's Oxford emphasizes Southern food that is raised to new and unusual heights. Lunch offers a wide array of excellent sandwiches, salads and business entrees, while dinner leans toward the more elaborate and inventive. Our commitment to a relaxed atmosphere and charming personality has McEwen's destined to become one of Oxford's most popular destinations. We boast on employing a knowledgeable and attentive staff that is always ready to serve our guests. In addition to the bar and dining room, a private room is available for parties up to 25 people.

Top review

Todd

Dined on 30 Oct 2026

Our Go to spot in Oxford. Always delivers. Always good.

Restaurant 1818 at Monmouth Historic Inn & Gardens

4.8

4.8 (543)

$31 to $50

American

Natchez

About the restaurant

At Restaurant 1818 you will dine in what was originally the Men's and Ladies’ Parlors of the Main House. These two parlors are adorned with authentic period crystal gasoliers. These impressive reproduction chandeliers and wall sconces were custom made for Monmouth by the artisans at Waterford Crystal in Ireland.

Guests have complete dining freedom when they reserve a table at Restaurant 1818. Here guests can select menu items on an a la carte basis from the gourmet appetizers, soups, salads, entrees, and desserts offered that evening. A full wine list and wine by the glass program is available to ensure your dining experience is the very best Natchez has to offer!

Private dining by candlelight is also offered for 8 to 12 people at the main dining room table. This room exemplifies the elegant dining experience which has been customary since the days of John and Eliza Quitman.

Top review

johnny

Dined 3 days ago

1818 was a great experience and Gia was a wonderful server, helpful, kind, and informative. Food was excellent, atmosphere even better. Recommend 100%.

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Popular dish

Moulard Duck Breast

Park Heights

4.8

4.8 (577)

$31 to $50

American

Tupelo

About the restaurant

Recently named the Best Fining Dining Restaurant in Mississippi by Mississippi Magazine and located in the Fairpark District, Park Heights offers Chef Thomas Lester's menu including seared hanger steak, yellowfin tuna tartar, heirloom tomato caprese, prosciutto wrapped monkfish and prime cuts of beef. The main dining room, with its reclaimed hardwood floors and retro lighting, provides an atmosphere that is sophisticated without feeling formal. Often sited as the best in town, the service is professional and gracious, and the wine list is extensive. If you enjoy dining al fresco, try the rooftop or patio which have amazing views of downtown.

Top review

barney

Dined on 22 Oct 2026

Very quiet dinner, wonderful food and service! Highly recommend!

Patio 44

4.5

4.5 (230)

$30 and under

American

Hattiesburg

About the restaurant

A unique patio style restaurant in the Hub City with delicious food, tasty cocktails and comfortable atmosphere. Patio 44 features creole cuisine and an extensive wine and premium spirits list.

Top review

CRYSTAL

Dined on 17 Oct 2026

Sat at the bar for dinner. Had great server and food!

Hard Rock Cafe - Biloxi

4.4

4.4 (581)

$30 and under

American

Biloxi

About the restaurant

Set along the sparkling shores of the Mississippi Gulf Coast, Hard Rock Cafe Biloxi delivers the perfect mix of Southern charm, coastal views, and the brand’s signature energy. Guests can dig into Hard Rock favorites like our Legendary Smashed Burger, Baby Back Ribs, and Crafted Cocktails while enjoying a front-row seat to one of the most vibrant gaming and entertainment destinations in the South. Surrounded by authentic music memorabilia and just steps from Biloxi’s bustling casino scene and sandy beaches, this cafe is a can’t-miss stop for locals and visitors alike. Whether you’re here for the flavors, the atmosphere, or the ocean breeze, Hard Rock Cafe Biloxi sets the stage for unforgettable dining on the Gulf Coast.

Top review

Teri

Dined on 24 Oct 2026

They food was really good and it was worth the price we paid for it and I would return again.

Patio 44-Gulfport

4.7

4.7 (484)

$30 and under

American

Gulfport

About the restaurant

Polished casual dining serving the finest coastal seafood and steaks on the Mississippi Gulf Coast. Featuring the regions best selection of premium wines and spirits. Relaxed ambiance with a scenic view from our patio of the Gulfport Harbor and Jones Park.

Top review

JoseGold

Dined on 30 Oct 2026

Great food, excellent service from Casey! Will become a repeat customer!

The Library Restaurant and Bar

4.6

4.6 (48)

$50 and over

American

Gulfport

About the restaurant

Located inside The Markham Hotel, The Library Restaurant & Bar offers a modern dining and cocktail experience in the heart of downtown Gulfport. With a striking central bar, breakfast, weekend brunch, dinner, handcrafted cocktails, and a nightly bar and tapas menu, The Library is designed for everything from quiet mornings to polished evenings out.

Top review

Joshua

Dined on 31 Oct 2026

Great food and fast service and professional ggggg

The Ranch

4.5

4.5 (55)

$30 and under

American

Starkville

About the restaurant

The Ranch is a contemporary American restaurant rooted in the flavors, traditions, and hospitality of the Southeast. Our menu highlights familiar Southern ingredients and regional influences through a fresh, chef-driven approach — balancing comfort, craft, and seasonality.

Guests can expect thoughtfully prepared dishes, warm service, and a welcoming atmosphere built for everything from casual lunches and family dinners to Sunday brunch. With a focus on quality ingredients, approachable flavors, and modern technique, The Ranch offers a refined but comfortable dining experience inspired by the foodways of the southeastern United States

Top review

Lamiaa

Dined 2 days ago

Very nice, but noisy given they sat us near the bar area. Otherwise, it was a great experience!

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