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M Brothers Restaurant - By the Medure Brothers - M Brothers at Mayo, Jacksonville, FL

M Brothers at Mayo

4.7
4.7
393 Reviews
$50 and over
Seafood
Located inside Jacksonville's Mayo Clinic, M Brothers is the newest venture by the Medure Brothers, Chef Matthew and David Medure. Our menu has a focus on fresh seafood with an Asian and Mediterranean flair. Visit our lounge for a craft cocktail or select a bottle of wine from our extensive list. Serving Lunch and Dinner Monday - Saturday.

Make a booking

2 people

7:00 pm


Booked 5 times today
Experiences are available.

Dining areas

Additional information

  • Dining style
    Fine Dining
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Hours of Operation
    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm
  • Phone number
    (904) 953-0409
  • Dress Code
    Casual Dress

Experiences

  • Brazil "If It Grows Together, It Goes Together"

    USD 80.00 per person

    20 Apr 2024 only
    Join us on Saturday, April 20th, 2024. This experience is $80 per person and $125 with wine pairings. This month's prix fixe menu is inspired by the flavors of Brazil and accompanied by Portuguese wine pairings.
    Brazil "If It Grows Together, It Goes Together" photo
  • Australia "If It Grows Together, It Goes Together"

    USD 80.00 per person

    25 May 2024 only
    Join us on Saturday, May 25th, 2024. This experience is $80 per person and $125 with wine pairings. This month's prix fixe menu is inspired by the flavors of Australia!
    Australia "If It Grows Together, It Goes Together" photo
  • Italian Piedmont "Grows Together/Goes Together"

    USD 80.00 per person

    22 June 2024 only
    Join us on Saturday, June 22nd, 2024. This experience is $80 per person and $125 with wine pairings. This month's prix fixe menu is inspired by the flavors of the Italian Piedmont!
    Italian Piedmont "Grows Together/Goes Together" photo

What 393 people are saying

Overall ratings and reviews

Reviews can only be made by diners who have eaten at this restaurant

4.7
4.7 based on recent ratings
  • 4.7Food
  • 4.7Service
  • 4.7Ambience
  • 4.4Value

NoiseModerate

Loved For

  • Jacksonville / Northeast Florida

    Good for business meals

  • Jacksonville / Northeast Florida

    Innovative

  • Jacksonville / Northeast Florida

    Healthy

  • Jacksonville / Northeast Florida

    Seafood

  • Jacksonville

    Best Food

  • Jacksonville

    Good for business meals

  • Jacksonville

    Innovative

  • Jacksonville

    Healthy

  • Jacksonville

    Great for fine wines

393 Reviews
  1. goodmealpriceless

    Jacksonville

    9 reviews

    vip
    3.0

    9 reviews

    Dined on 5 April 2024

    1. Overall 3
    2. Food 3
    3. Service 4
    4. Ambience 2
    Not impressed at all with food. Ribeye was < 1/4 inch thick, I ordered med-rare. It was medium in some places rare in others and well done in others. Seemed like a bad cut of meat, it was very dry. Daughter had tuna poke bowl. It was fresh but needed sauce, it had none! Didn’t let manager know because I ate at least 1/3 of it before server came back and they were fine serving a cut of meat that was that thin anyway. Won’t go back.

    Is this helpful?

  2. Quickdraw1

    San Francisco

    40 reviews

    vip
    4.0

    40 reviews

    Dined on 4 April 2024

    1. Overall 4
    2. Food 4
    3. Service 5
    4. Ambience 5
    Destanee, our server, and our lady that refilled our water (Christina?) were excellent. All the people we interacted with were enthusiastic, happy and well trained in their jobs and Liked their jobs! Artichoke soup was great as was the buttermilk ice cream. Beet and orange salad was a nice combo. My ribeye was so, so too tough and lacking flavor. Heard another table say their rib eye was great. Salmon, shrimp and grits were good. We will be back.

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  3. AmberS

    Jacksonville

    7 reviews

    vip
    5.0

    7 reviews

    Dined on 2 April 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Fantastic food! Excellent service!! Love this place! The bread is divine

    Is this helpful?

  4. OpenTable Diner

    Jacksonville

    3 reviews

    5.0

    3 reviews

    Dined on 2 April 2024

    1. Overall 5
    2. Food 4
    3. Service 5
    4. Ambience 5
    We loved our lunch at M Brothers. The food was great, atmosphere wonderful, attention by the servers outstanding. It was an all around A+ dining experience. Thanks to all!
    M Brothers at MayoResponded on 4 April 2024
    Thank you so much for the wonderful review! We hope to see you soon.

    Is this helpful?

  5. OpenTable Diner

    Orlando

    7 reviews

    vip
    5.0

    7 reviews

    Dined on 1 April 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Great evening with two friends who had not been before. Great wine list and excellent entrees.
    M Brothers at MayoResponded on 4 April 2024
    Thanks so much!

    Is this helpful?

  6. THOMASH

    Charleston

    16 reviews

    vip
    5.0

    16 reviews

    Dined on 1 April 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Excellent! Kaitleen and Jeff are true credits to M!

    Is this helpful?

  7. OpenTable Diner

    Naples

    1 review

    5.0

    1 review

    Dined on 1 April 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Incredible dining to forget about the day’s events at a hospital. Presentation was incredible as was the flavor!

    Is this helpful?

  8. Voyager

    Charleston

    43 reviews

    5.0

    43 reviews

    Dined on 28 March 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    I make a point to eat at M Brothers every time I visit Mayo Clinic. It's a wonderful addition to the campus. Friendly greetings, good service, excellent food. A very nice setting. Well worth the visit.

    Is this helpful?

  9. OpenTable Diner

    Coastal Georgia

    2 reviews

    5.0

    2 reviews

    Dined on 25 March 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Great food & service. Being at Mayo often comes with stress, it’s nice to have a convenient place to have a great meal.

    Is this helpful?

  10. JBDPVB

    Jacksonville

    16 reviews

    vip
    5.0

    16 reviews

    Dined on 23 March 2024

    1. Overall 5
    2. Food 5
    3. Service 4
    4. Ambience 5
    We enjoyed the Japanese Tasting menu with the paired sake. Our food and the ambience were excellent. It was the first time our service wasn’t up to par with the elevated food experience.

    1 person found this helpful

FAQs

M Brothers at Mayo is rated 4.7 stars by 393 OpenTable diners.

Yes, you can generally book this restaurant by choosing the date, time and party size on OpenTable.

Make a booking

2 people

7:00 pm


Booked 5 times today
Experiences are available.
Google Map for M Brothers at Mayo

14335 Hospital Drive Suite 100, Jacksonville, FL 32224

Dining areas

Additional information

  • Cross Street
    San Pablo to W. Davis. Turn into Garage and look for complimentary VALET.
  • Area
    Jacksonville
  • Hours of Operation
    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Dining style
    Fine Dining
  • Dress Code
    Casual Dress
  • Parking Details
    Valet
  • Additional
    Bar/Lounge, Chef's Table, Non-Smoking, Private Room
  • Privacy policy
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